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Hosp Pract (1995). 1995 Oct 15;30(10):31-4, 37-42.

The changing immunology of organ transplantation.

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  • 1University of Pittsburgh, USA.

Abstract

The engrafted organ becomes a chimera as the recipient's leukocytes station themselves in the transplant. Remarkably, the recipient becomes chimeric as well, in a reverse migration involving immune cells from the graft. Interactions between donor and recipient cells are tolerogenic--a process with implications for the goal of graft acceptance with minimal immunosuppression.

PMID:
7593387
PMCID:
PMC2978538
[PubMed - indexed for MEDLINE]
Free PMC Article
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