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Invest Ophthalmol Vis Sci. 1995 Nov;36(12):2461-5.

Prostaglandin F2 alpha effects on isolated rhesus monkey ciliary muscle.

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1
Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison 53792-3220, USA.

Abstract

PURPOSE:

The effects of prostaglandin (PG)F2 alpha on the contractile response in the longitudinal and coronal vectors of the isolated rhesus monkey ciliary muscle were studied.

METHODS:

Fresh rhesus monkey ciliary muscle strips from young and middle-aged animals were mounted in an apparatus capable of monitoring contractile force simultaneously in the two vectors. The responses to PGF2 alpha were measured and compared to those produced with 1 microM carbachol.

RESULTS:

PGF2 alpha consistently relaxed the carbachol precontracted ciliary muscle in a dose-dependent manner with equal potency and efficacy in both vectors, but it did not alter the tone of muscle strips at resting tension.

CONCLUSIONS:

The relaxation of precontracted ciliary muscle by PGF2 alpha may help explain how a single topical dose of this prostanoid increases uveoscleral outflow and antagonizes resting myopia in the living monkey.

PMID:
7591635
[Indexed for MEDLINE]
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