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Horm Metab Res. 1995 Aug;27(8):372-5.

Physiological effect of glucagon in human isolated adipocytes.

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  • 1Department of Metabolism, Nutrition and Hormones, Fundación Jiménez Díaz, Madrid, Spain.

Abstract

In human isolated adipocytes, glucagon induces a dose dependent increment of the glycerol release, which is already observed at physiological concentrations of the hormone. Furthermore, glucagon at 10(-8) M, significantly stimulates the adenylate cyclase activity in both non-solubilized and solubilized fat plasma membranes, and at already 10(-11) M, a significant increment of the adipocyte cAMP content is observed. These data support previous in vivo positive results indicating that glucagon plays a role in human fat metabolism.

PMID:
7590626
DOI:
10.1055/s-2007-979981
[PubMed - indexed for MEDLINE]
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