Format

Send to

Choose Destination
FEMS Microbiol Lett. 1995 Oct 1;132(1-2):107-14.

Induction of vancomycin resistance in Enterococcus faecium by non-glycopeptide antibiotics.

Author information

1
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.

Abstract

Bacitracin and other antibiotics that inhibit late stages in peptidoglycan biosynthesis induce vancomycin resistance in a high-level, inducibly vancomycin-resistant strain of Enterococcus faecium. Exposure to bacitracin led to synthesis of the lactate-containing UDP-MurNAc-pentadepsipeptide precursor required for vancomycin resistance. These findings indicate that inhibition of peptidoglycan biosynthesis can lead to induction of vancomycin resistance and raise the possibility that multiple signals may serve to induce resistance.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center