Format

Send to

Choose Destination
See comment in PubMed Commons below
FEBS Lett. 1995 Nov 6;374(3):323-6.

The platelet endothelial cell adhesion molecule-1 (PECAM1) contributes to endothelial barrier function.

Author information

1
Laboratory of Adoptive Immunotherapy, Scientific Institute San Raffaele, Milan, Italy.

Abstract

In this study we have analyzed the role of the platelet-endothelial cell adhesion molecule-1 (PECAM1) in vascular barrier function. PECAM1 is an immunoglobulin gene superfamily member expressed by endothelial cells at the cell boundaries. Macromolecule permeability assays performed on cell monolayers that express native or transfected PECAM1, indicated that the molecule participates in the establishment and maintenance of vascular barrier function in vitro. This hypothesis was confirmed by the finding that in vivo injection of the specific monoclonal antibody directed against the murine vascular PECAM1 led to a detectable leakage of hepatic and renal blood vessels.

PMID:
7589563
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center