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FEBS Lett. 1995 Oct 30;374(2):270-2.

Expression of cytochrome P450 CYP1B1 in breast cancer.

Author information

1
Department of Pathology, University of Aberdeen, UK.

Abstract

The expression of CYP1B1 has been identified in breast cancer using the reverse transcriptase-polymerase chain reaction and immunoblotting. CYP1B1 mRNA was expressed in the majority of breast tumours and immunoblotting of breast tumours identified a single protein band of molecular weight 60 kDa corresponding to the predicted molecular weight of human CYP1B1. This is the first study to identify CYP1B1 expression in a tumour where it may represent a previously unknown pathway for the metabolism of oestradiol and chemotherapeutic drugs.

PMID:
7589551
DOI:
10.1016/0014-5793(95)01126-y
[Indexed for MEDLINE]
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