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FEBS Lett. 1995 Oct 16;373(3):193-8.

Molecular cloning of a widely expressed human homologue for the Drosophila trp gene.

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  • 1Department of Anesthesiology and Biological Chemistry, UCLA School of Medicine 90095-1778, USA.


The Drosophila transient receptor potential (trp) gene and its homologue, trpl, have been suggested to mediate calcium entry during the insect's phototransduction process. We isolated a human cDNA, human trp-1 (Htrp-1), encoding a polypeptide of 793 amino acids that is 37% identical (62% similar) to Drosophila trp and trpl. Northern analysis showed that the Htrp-1 transcript is approximately 5.5 kb and expressed in most human tissues, with higher amounts in ovary, testis, heart, and brain. Isolation of Htrp-1 suggests that a trp-type protein is present in mammals and should provide a useful tool in studying calcium-depletion induced calcium influx processes.

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