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Eur J Pharmacol. 1995 Jul 1;293(2):141-9.

The biochemical effects of clenbuterol: with particular reference to taurine and muscle damage.

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Department of Toxicology, School of Pharmacy, University of London, UK.


Administration of clenbuterol to rats in the drinking water over a 4 day period increased incorporation of [3H]leucine into muscle protein and caused a slight reduction in urinary 3-methylhistidine but did not result in an increase in body or muscle weight. However, both urinary and liver taurine were significantly reduced at the highest dose of clenbuterol (2 Serum creatine kinase, muscle isoenzyme (CK-MM) was raised and single muscle fibre injury was observed in the soleus muscle in animals treated with the middle dose (0.2 and highest dose (2 The reduction in the body pool of taurine caused by clenbuterol is of concern as taurine has been shown to have protective properties.

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