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Eur J Immunol. 1995 Oct;25(10):2830-4.

Altered CD40 ligand induction in tolerant T lymphocytes.

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Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA.


CD40 ligand (CD40L) is a member of the tumor necrosis factor superfamily and is expressed on the surface of activated T lymphocytes. The interaction of CD40L with CD40 on B cells results in B cell activation, immunoglobulin (Ig) secretion and Ig class switching. To study anergy as a mechanism of murine CD4 T cell tolerance, we determined both in vivo and in vitro that CD3-activated anergic cells are deficient in the ability to stimulate B cell proliferation, and that anergic cells are defective for the T cell receptor/CD3-mediated induction of CD40L expression. These results have implications for the recruitment of B cell responses by anergic T cells in vivo.

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