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Endocr Res. 1995 Aug;21(3):697-707.

The binding of recombinant human relaxin to human spermatozoa.

Author information

1
Division of Urology, University of Utah School of Medicine, Salt Lake City 81432, USA.

Abstract

Porcine relaxin has been reported to stimulate various human sperm functions. In this paper we report that human recombinant relaxin binds to human sperm with a high affinity (Kd = 6.5 x 10(-10)). The bound 125I-relaxin was not displaced by insulin, or human chorionic gonadotropin, however, it was displaced by unlabeled relaxin. In sperm function studies, recombinant human relaxin stimulated sperm motility, zona-free hamster egg penetration, and the acrosome reaction.

PMID:
7588437
DOI:
10.1080/07435809509030484
[Indexed for MEDLINE]

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