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Nat Med. 1995 Jan;1(1):27-31.

Angiogenesis in cancer, vascular, rheumatoid and other disease.

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Children's Hospital, Boston, Massachusetts, USA.


Recent discoveries of endogenous negative regulators of angiogenesis, thrombospondin, angiostatin and glioma-derived angiogenesis inhibitory factor, all associated with neovascularized tumours, suggest a new paradigm of tumorigenesis. It is now helpful to think of the switch to the angiogenic phenotype as a net balance of positive and negative regulators of blood vessel growth. The extent to which the negative regulators are decreased during this switch may dictate whether a primary tumour grows rapidly or slowly and whether metastases grow at all.

[Indexed for MEDLINE]

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