Format

Send to

Choose Destination
Immunity. 1995 Nov;3(5):583-90.

The MHC class I homolog encoded by human cytomegalovirus binds endogenous peptides.

Author information

1
Division of Biology, California Institute of Technology, Pasadena 91125, USA.

Abstract

The ability of a human cytomegalovirus-encoded homolog of MHC class I molecules to serve as a peptide receptor was investigated. Sequencing of peptide material eluted from the purified viral protein revealed a mixture of endogenous peptides with characteristics similar to those eluted from conventional class I molecules, that is, anchor residues, and a predominance of short peptides derived from cytoplasmic proteins. The possible function(s) of this viral MHC homolog are discussed in light of the finding that it binds endogenous peptides.

PMID:
7584148
DOI:
10.1016/1074-7613(95)90129-9
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center