Format

Send to

Choose Destination
Neurodegeneration. 1995 Jun;4(2):203-7.

MRI assessment of the blood-brain barrier in a hamster model of scrapie.

Author information

1
Robert Steiner MR Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London.

Abstract

Magnetic resonance (MR) imaging in combination with gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) enhancement was used to investigate the integrity of the blood-brain barrier in a hamster model of scrapie (263K) during the clinical phase of the disease. The post Gd-DTPA images of the infected hamster brain showed marked enhancement, which was not present in control animals. These results suggest that blood-brain barrier function is disrupted in the clinically-affected animal.

PMID:
7583685
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center