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Curr Opin Struct Biol. 1995 Jun;5(3):409-16.

Proteins with leucine-rich repeats.

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St Vincent's Institute of Medical Research, Fitzroy, Australia.


Leucine-rich repeats are short sequence motifs present in over sixty proteins, all of which appear to be involved in protein-protein interactions. The crystal structure of ribonuclease inhibitor demonstrated that the repeats correspond to beta-alpha structural units. The recently determined crystal structure of the ribonuclease A-ribonuclease inhibitor complex suggests the basis for the protein-binding function of leucine-rich repeats.

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