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Nat Genet. 1995 Nov;11(3):294-300.

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver.

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Osaka Bioscience Institute, Japan.


Fas, a type I membrane protein that transduces an apoptotic signal, is expressed in lymphocytes as well as in various tissues such as the liver, lung and heart. The mouse lymphoproliferation (lpr) mutation is a leaky mutation in Fas. By means of gene targeting, we generated a mouse strain which is completely deficient in Fas. In addition to the massive production of lymphocytes, the Fas-null mice showed substantial liver hyperplasia, which was accompanied by the enlargement of nuclei in hepatocytes. The Fas system seems to play a role in the apoptotic process to maintain homeostasis of the liver as well as the peripheral lymphoid organs.

[Indexed for MEDLINE]

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