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DNA Seq. 1995;5(5):273-5.

Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library.

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Department of Biochemistry, Faculty of Dentistry, Tokyo Medical and Dental University, Japan.


A cDNA clone encoding bone morphogenetic protein-4 (BMP-4) has been isolated from a human placental cDNA library. Sequence analysis of this clone revealed that the nucleotide sequence of 5' region was different from that of human osteosarcoma BMP-4 and the deduced amino acid sequence indicated deletion of N-terminal 6 amino acids. We confirmed the expression of this type of BMP-4 mRNA in one human osteogenic cell line in addition to the placenta by the polymerase chain reaction (PCR).

[Indexed for MEDLINE]

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