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Biochim Biophys Acta. 1995 Oct 10;1231(3):215-9.

Cytochrome b-558 alpha-subunit cloning and expression in rat aortic smooth muscle cells.

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Department of Medicine, Emory University, Atlanta, GA 30322, USA.


Recent studies have shown that the NADPH oxidase participates in the generation of superoxide anion in non-phagocytic cells. Here we report the isolation and nucleotide sequence of a cDNA for the cytochrome b-558 alpha-subunit of the NADPH oxidase in rat vascular smooth muscle cells (VSMCs). The coding region of the cDNA was 93% homologous to mouse and 81% to human in nucleotide sequence and 96% homologous to mouse and 89% to human in the deduced amino acid sequence. Our results provide a tool with which to explore the mechanism of superoxide anion generation in rat VSMCs and other non-phagocytic cells.

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