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Neuron. 1995 Oct;15(4):829-42.

Molecular cloning of linotte in Drosophila: a novel gene that functions in adults during associative learning.

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1
Cold Spring Harbor Laboratory, New York 11724, USA.

Erratum in

  • Neuron 2002 May 16;34(4):667.

Abstract

The linotte (lio) gene was identified in a screen for mutations that disrupted 3 hr memory after olfactory associative learning, without affecting the perception of odors or electroshock. The mutagenesis yielded a transposon-tagged gene disruption, which allowed rapid cloning of genomic DNA. The lio transcription unit was identified via rescue of the lio1 learning/memory defect by induced expression of a lio+ transgene in adults. The perception of odors or electroshock remained normal when the lio+ transgene was expressed in these lio1 flies. Learning/memory remained normal when the lio+ transgene was expressed in wild-type (lio+) flies. The lio gene produces only one transcript, the level of expression of which varies throughout development. Sequence analysis indicates that lio encodes a novel protein.

PMID:
7576632
[Indexed for MEDLINE]
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