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AIDS. 1995 Aug;9(8):909-12.

HIV infection and invasive cervical carcinoma in an Italian population: the need for closer screening programmes in seropositive patients.

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Department of Obstetrics and Gynaecology, S. Gerardo Hospital, University of Milan, Monza, Italy.



To evaluate in an Italian population the prevalence, characteristics at first diagnosis and outcome of HIV-seropositive individuals with cervical carcinoma referred to a tertiary-care institution.


A retrospective evaluation of all patients referred for invasive cervical carcinoma from 1991 to 1994.


The departments of obstetrics and gynaecology, and radiotherapy at San Gerardo Hospital, University of Milan, Italy.


A total of 340 women were treated over a 3-year period (186 aged < 50 years). Six patients were found to be HIV-seropositive.


Seropositive patients were treated according to current institutional protocols, irrespective of HIV status. Four underwent radiotherapy and two radical hysterectomy as primary treatment.


Although five HIV-seropositive patients were known to be infected 13-81 months before diagnosis of cervical cancer, none had received a PAP smear in the last year and only one in the last 2 years. HIV patients were younger than general population (P = 0.02), with a significant history of intravenous drug use (P = 0.000001) and with more advanced disease (P = 0.04). Two HIV-positive patients also received polychemotherapy (one adjuvant and one salvage treatment) and both completed the planned treatment. Within 24 months two patients had died of cancer and one of AIDS; one is alive with AIDS and cancer and two are free of disease.


This study confirms that in a southern European population, HIV-seropositive women present to tertiary-care institutions with more advanced disease and have a poorer prognosis than the general population. Strict screening programs for cervical dysplasia and cancer are warranted for HIV-seropositive patients.

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