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Immunol Today. 1995 Oct;16(10):487-94.

Loss of HLA class I antigens by melanoma cells: molecular mechanisms, functional significance and clinical relevance.

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Dept of Microbiology and Immunology, New York Medical College, Valhalla 10595, USA.


Malignant transformation of melanocytes may be associated with changes in the expression of major histocompatibility complex (MHC) HLA class I antigens. Interest in the characterization of abnormalities in the expression of MHC class I by melanoma cells has been rekindled by the current emphasis on the application of T-cell-based immunotherapy to melanoma. Here, Soldano Ferrone and Francesco Marincola review defects in class I expression as described in melanoma cells, as well as the molecular mechanisms, functional significance and clinical implications of such defects.

[Indexed for MEDLINE]

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