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Biochem Biophys Res Commun. 1995 Sep 25;214(3):963-70.

Structural analysis of invasion plasmid antigen D (IpaD) from Shigella flexneri.

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1
Department of Biology, Saint Louis University, MO 63103-2010, USA.

Abstract

Invaison plasmid antigen D (IpaD) and water-extracted outer-membrane proteins (OMPs) from Shigella flexneri were used to investigate some of the structural relationships of this pathogen's invasions. Extracellular presentation of the three invasion plasmid antigens (Ipa) B, C, and D is required for the S. flexneri invasive phenotype; however, little is known of the structural properties of these essential virulence components. Biochemical data suggest IpaB, C, and D present in S. flexneri OMPs from soluble protein complexes and IpaD may be able to form large homopolymeric complexes.

PMID:
7575570
DOI:
10.1006/bbrc.1995.2380
[Indexed for MEDLINE]

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