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Biochem Biophys Res Commun. 1995 Sep 25;214(3):755-9.

Flavonoids as scavengers of nitric oxide radical.

Author information

1
LACDR, Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, Amsterdam, The Netherlands.

Abstract

Flavonoids are a group of naturally occurring compounds used, e.g., in the treatment of vascular endothelial damage. They are known to be excellent scavengers of oxygen free radicals. Since the nitric oxide radical (.NO) probably plays a role in this pathology, the .NO scavenging capacity of the flavonoids was determined. It was found that the flavonoids are very potent .NO scavengers. The anthocyanidins were found to be more effective scavengers than the hydroxyethylrutosides, which correlated with their therapeutic activity. The values of their scavenging rate constants are only 30 times less active than the very potent endogenous .NO scavenger haemoglobin. It is speculated that .NO scavenging plays a role in the therapeutic effect of the flavonoids.

PMID:
7575540
DOI:
10.1006/bbrc.1995.2350
[Indexed for MEDLINE]

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