Molecular mechanisms of APO-1/Fas(CD95)-mediated apoptosis in tolerance and AIDS

J Dhein; H Walczak; M O Westendorp; C Bäumler; K Stricker; R Frank; K M Debatin; P H Krammer

Molecular mechanisms of APO-1/Fas(CD95)-mediated apoptosis in tolerance and AIDS

Behring Inst Mitt. 1995 Jun:(96):13-20.

Authors

J Dhein¹, H Walczak, M O Westendorp, C Bäumler, K Stricker, R Frank, K M Debatin, P H Krammer

Affiliation

¹ Tumorimmunology Program, German Cancer Research Center, Heidelberg.

PMID: 7575348

Abstract

The cell surface molecule APO-1/Fas(CD95), a member of the Tumor Necrosis Factor (TNF) receptor/Nerve Growth Factor (NGF) receptor superfamily mediates apoptosis upon cross-linking by agonistic antibodies or its ligand. Recent findings suggest that APO-1/Fas(CD95) and its ligand are the key molecules for antigen receptor-induced apoptosis in activated mature T cells. Here we propose a mechanism for antigen receptor-induced apoptosis of activated T cells via APO-1 ligand mediated autocrine suicide. This mechanism may also contribute to the depletion of CD4+ T cells in AIDS.

Publication types

Review

MeSH terms

Acquired Immunodeficiency Syndrome / immunology*
Animals
Antigens, CD / genetics
Antigens, CD / immunology
Antigens, CD / physiology*
Apoptosis*
Autoimmune Diseases / genetics
Autoimmune Diseases / immunology
Humans
Immune Tolerance*
Models, Immunological
Mutation
Receptors, Nerve Growth Factor / physiology
Receptors, Tumor Necrosis Factor / physiology
T-Lymphocytes / immunology*
fas Receptor / genetics
fas Receptor / immunology
fas Receptor / physiology*

Substances

Antigens, CD
Receptors, Nerve Growth Factor
Receptors, Tumor Necrosis Factor
fas Receptor