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Am J Obstet Gynecol. 1995 Sep;173(3 Pt 1):881-4.

Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial.

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Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Thailand.



Our purpose was to determine the effectiveness of pyridoxine for nausea and vomiting of pregnancy.


During an 11-month period 342 women who first attended Chiang Mai University Hospital antenatal clinic at < or = 17 weeks' gestation were randomized to received either oral pyridoxine hydrochloride, 30 mg per day, or placebo in a double-blind fashion. Patients graded the severity of their nausea by a visual analog scale and recorded the number of vomiting episodes over the previous 24 hours before treatment and again during 5 consecutive days on treatment.


There was a significant decrease in the mean of posttherapy minus baseline nausea scores in the pyridoxine compared with that in the placebo group (t test, p = 0.0008). There was also a greater reduction in the mean number of vomiting episodes, but the differences did not reach statistical significance (p = 0.0552).


Pyridoxine is effective in relieving the severity of nausea in early pregnancy.

[Indexed for MEDLINE]

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