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Am J Gastroenterol. 1995 Oct;90(10):1829-33.

Electron microscopic study of association between coccoid forms of Helicobacter pylori and gastric epithelial cells.

Author information

1
Department of Histology and Embryology, Military Medical Academy, Lodz, Poland.

Abstract

OBJECTIVE:

To investigate the relationship between helical and coccoid forms of Helicobacter pylori and gastric epithelial cells.

METHODS:

Gastric antral and body biopsies were obtained from eight children, aged 10-17 yr, who underwent diagnostic gastroscopy. Specimens were processed for electron microscopy. The location of organisms and ultrastructural features were assessed with a transmission electron microscope.

RESULTS:

We observed two morphological forms of bacteria in three of eight H. pylori-positive patients. Helical forms were localized only in the proximity to unchanged or variously damaged mucous cells, but coccoid forms were present only above strongly damaged epithelial cells.

CONCLUSION:

Coccoid forms of H. pylori are closely associated with damaged gastric mucous cells. Possible explanations for this phenomenon are discussed.

PMID:
7572903
[Indexed for MEDLINE]

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