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Acta Cytol. 1995 Sep-Oct;39(5):951-4.

Alveolar soft part sarcoma. Report of a case diagnosed by needle aspiration cytology and electron microscopy.

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  • 1Department of Laboratory Medicine, Sinai Hospital, Detroit, Michigan 48235, USA.

Abstract

BACKGROUND:

Alveolar soft part sarcoma (ASPS) is a rare tumor, accounting for less than 1% of all primary soft tissue malignant neoplasms. The tumor is a distinct clinicopathologic entity, but its histogenesis is controversial.

CASE:

The needle aspirate from a soft tissue tumor in a 15-year-old girl was stained with Diff-Quik and periodic acid--Schiff (PAS) with and without prior digestion with diastase. Minute tumor tissue fragments were processed for transmission electron microscopic examination (EM). Clustered malignant cells with ill-defined, frothy or vacuolated cytoplasm showed a positive reaction with PAS and PAS with prior diastase digestion and oval nuclei containing macronucleoli. Intracytoplasmic, membrane-bound, rhomboid and rod-shaped crystals with a regular lattice pattern with 50-80 A periodicity were detected by EM study of aspirated tumor cells.

CONCLUSION:

Light and EM studies of aspirated tumor cells showed diagnostic features of the tumor.

PMID:
7571976
[PubMed - indexed for MEDLINE]
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