Industry continues to promote the use of sound science in regulatory decision making. The use of decision support methodologies for hazard identification/risk assessment of toxic substances such as models employing physiologically based pharmacokinetics (PBPK) and structure-activity relationships (SAR) are recommended. A collaborative program involving government and industry is needed to further the use of these decision support methodologies. The formation of federal and state working groups is recommended. Organizations such as the Halogenated Solvents Industrial Alliance (HSIA), American Industrial Health Council (AIHC), and the Chemical Manufacturers Association (CMA) are suitable industry representatives.