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Semin Nephrol. 1995 Jul;15(4):291-9.

Growth factors in renal development.

Author information

1
George M. O'Brien Kidney and Urological Diseases Center, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.

Abstract

The formation of all organs during embryogenesis, including the kidney, is dependent on the timed and sequential expression of a number of polypeptide growth factors. Synthesis and actions of one or more members of the insulinlike growth factor (IGF), epidermal growth factor/transforming growth factor-alpha (EGF/TGF-alpha), transforming growth factor-beta (TGF-beta), platelet-derived growth factor (PDGF), fibroblast growth factor (FGF), hepatocyte growth factor (HGF), and nerve growth factor (NGF) families have been characterized in the developing metanephric kidney. Studies originating from a number of laboratories have defined the localization of growth factor mRNAs, receptors and peptides, have delineated patterns of growth factor synthesis, have established the growth factor-dependency of embryonic kidney development, and have identified abnormalities of growth factor-expression as potentially causative of aberrancies in metanephrogenesis. The results of these investigations are summarized in this review.

PMID:
7569409
[Indexed for MEDLINE]

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