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Prog Cardiovasc Dis. 1995 Sep-Oct;38(2):129-54.

Atherosclerosis, oxidative stress, and antioxidant protection in endothelium-derived relaxing factor action.

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Evans Memorial Department of Medicine, Boston University Medical Center, MA, USA.


The vascular endothelium plays a central role in the regulation of vascular function. In particular, the local release of endothelium-derived relaxing factor (EDRF) regulates vascular tone and prevents platelet adhesion to the vascular wall. Impairment of EDRF action develops early in atherosclerosis and, in part, contributes to platelet deposition and vasospasm involved in the clinical expression of coronary artery disease. Recent evidence suggests that an imbalance between vascular oxidative stress and antioxidant protection is involved in the development of this vascular dysfunction. In this report, the relation between oxidative stress, atherosclerosis, and abnormal EDRF action is reviewed with particular attention to the effects of antioxidant supplementation in animal models of atherosclerosis and hypercholesterolemia.

[Indexed for MEDLINE]

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