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Nature. 1995 Oct 5;377(6548):397-404.

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor.

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1
Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093-0648, USA.

Abstract

Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressors of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.

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PMID:
7566114
DOI:
10.1038/377397a0
[Indexed for MEDLINE]

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