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Nature. 1995 Sep 28;377(6547 Suppl):175-297.

A YAC contig map of the human genome.

Author information

1
Fondation Jean Dausset Centre d'Etude du Polymorphisme Humain, Paris, France.

Abstract

A yeast artificial chromosome library containing 33,000 clones with an average insert size of one megabase of human genomic DNA was extensively analysed by several different procedures for detecting overlaps and positional information. We developed an analysis strategy that resulted, after confirmatory tests, in a YAC contig map reliably covering about 75% of the human genome in 225 contigs having an average size of about ten megabases.

PMID:
7566096
DOI:
10.1038/377175a0
[Indexed for MEDLINE]
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