Presence of virion protein x (Vpx) of simian immunodeficiency virus SIVmac 251 in target cells in vivo

Y Persidsky; V Liska; T Huss; J L Gendrault; A Venet; E Muchmore; F Traincard; A Kirn; A M Aubertin

doi:10.1111/j.1600-0684.1995.tb00142.x

Presence of virion protein x (Vpx) of simian immunodeficiency virus SIVmac 251 in target cells in vivo

J Med Primatol. 1995 Jan;24(1):35-42. doi: 10.1111/j.1600-0684.1995.tb00142.x.

Authors

Y Persidsky¹, V Liska, T Huss, J L Gendrault, A Venet, E Muchmore, F Traincard, A Kirn, A M Aubertin

Affiliation

¹ Unité INSERM 74, Institut de Virologie de la Faculté de Médecine, Université Louis Pasteur, Strasbourg, France.

PMID: 7563009
DOI: 10.1111/j.1600-0684.1995.tb00142.x

Abstract

Localization of virion-associated protein x (Vpx) of SIVmac 251 was studied in lymph nodes and liver of six SIVmac-infected monkeys. Vpx was found associated with the network of follicular dendritic cells and macrophages in lymph nodes and/or livers from five out of six animals by immunohistochemistry. Although the humoral response to Vpx occurs in only 50% of the animals, the presence of Vpx in target cell or antibodies to Vpx in all the monkeys studied, suggests that Vpx may be necessary for viral replication in vivo.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies, Viral / blood
Female
Immunohistochemistry
Kupffer Cells / virology
Liver / virology*
Lymph Nodes / virology*
Macaca mulatta
Macrophages / virology
Male
Simian Acquired Immunodeficiency Syndrome / blood
Simian Acquired Immunodeficiency Syndrome / immunology
Simian Acquired Immunodeficiency Syndrome / virology*
Simian Immunodeficiency Virus / immunology
Simian Immunodeficiency Virus / isolation & purification
Simian Immunodeficiency Virus / physiology*
Time Factors
Viral Regulatory and Accessory Proteins / analysis*
Virus Replication

Substances

Antibodies, Viral
VPX protein, Simian immunodeficiency virus
Viral Regulatory and Accessory Proteins