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J Med Microbiol. 1995 Oct;43(4):258-61.

The influence of exo-enzyme S and proteases on endogenous Pseudomonas aeruginosa bacteraemia in mice.

Author information

1
Department of Microbiology, Toho University School of Medicine, Tokyo, Japan.

Abstract

The role of Pseudomonas aeruginosa exo-enzymes was evaluated in a murine model of endogenous bacteraemia in which the bacteria invaded the bloodstream after oral dosing. Although an elastase mutant PAO-E64 was as virulent as its parent strain PAO1, an exo-enzyme S-deficient mutant, DG1-ExS5 and alkaline protease mutants PAKS-16, PAKS-17, PAKS-19, were less virulent than their parent strains, DG1 and PAKS-1, respectively (p < 0.01). Thus exo-enzyme S and alkaline protease, but not elastase, appear to contribute to the pathogenicity of P. aeruginosa in this model.

PMID:
7562986
DOI:
10.1099/00222615-43-4-258
[Indexed for MEDLINE]

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