Format

Send to

Choose Destination
J Infect Dis. 1995 Oct;172(4):1023-7.

Anticryptococcal activity of NK cell-enriched peripheral blood lymphocytes from human immunodeficiency virus-infected subjects: responses to interleukin-2, interferon-gamma, and interleukin-12.

Author information

1
Department of Internal Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157, USA.

Abstract

Anticryptococcal activity of highly purified NK cells from patients with either early asymptomatic or late-stage human immunodeficiency virus (HIV) infection proved to be markedly impaired; activity was reproducibly restored to normal levels by in vitro addition of exogenous interleukin-12 (IL-12). For these highly purified NK cells, responses to IL-2 and interferon-gamma (IFN-gamma) among HIV-infected patients were variable, with only 2 of 8 exhibiting significant responses to IL-2 or IFN-gamma. In contrast, IL-2 and IFN-gamma consistently enhanced anticryptococcal activity of mixed lymphocyte populations, cells that more closely approximate the network likely to be operational in vivo.

PMID:
7561175
DOI:
10.1093/infdis/172.4.1023
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center