Regulation of sugar transport via the multiple sugar metabolism operon of Streptococcus mutans by the phosphoenolpyruvate phosphotransferase system

J Bacteriol. 1995 Oct;177(19):5704-6. doi: 10.1128/jb.177.19.5704-5706.1995.

Abstract

In this report, we provide evidence that the transport of sugars in Streptococcus mutans via the multiple sugar metabolism system is regulated by the phosphoenolpyruvate phosphotransferase system. A ptsI-defective mutant (DC10), when grown on the multiple sugar metabolism system substrate raffinose, exhibited reduced growth, transport, and glycolytic activity with raffinose relative to the parent strain BM71. Inhibition of [3H]raffinose uptake was also observed in both BM71 and DC10 with increasing concentrations of glucose and the glucose analogs alpha-methyl glucoside and 2-deoxyglucose.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Transport, Active
  • Glucose / metabolism*
  • Glycolysis
  • Operon
  • Phosphoenolpyruvate Sugar Phosphotransferase System / physiology*
  • Raffinose / metabolism*
  • Streptococcus mutans / growth & development
  • Streptococcus mutans / metabolism*

Substances

  • Phosphoenolpyruvate Sugar Phosphotransferase System
  • Glucose
  • Raffinose