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Genomics. 1995 May 20;27(2):320-8.

Complete sequence of the 43-kb human ribosomal DNA repeat: analysis of the intergenic spacer.

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Department of Pathology, Hahnemann University, Philadelphia, Pennsylvania 19102, USA.


We have sequenced the remaining 12.4 kb of the 30-kb human ribosomal DNA intergenic spacer (IGS), which allows us to piece together both a complete IGS and a 43-kb rDNA unit. The sequence of the complete IGS reveals a collection of sequence motifs that can be correlated with functions known or expected to reside in the rDNA repeat: modulation of transcription, recombination, initiation of DNA replication, and chromosomal organization. Finally, we find that IGS accumulates variation at a much higher rate than the transcribed regions. This finding leads us to correlate sequence character with types of mutation and sequence context with rate of mutation.

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