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Ther Immunol. 1995 Feb;2(1):23-9.

Low immunogenicity of therapeutic rat CD45 antibodies when used for pre-treatment of donor organs for transplantation.

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Cantab Pharmaceuticals Research Limited, Cambridge, UK.


Immunoassays for the measurement of human anti-immunoglobulin responses against the CD45 specific rat monoclonals, YTH 24.5 and YTH 54.12, have been developed. The assays are based on a 'double antigen' ELISA system and are reproducible with coefficients of variation of less than 15%. The assays were used to measure anti-immunoglobulin responses in sera from 40 patients who had received kidneys pre-treated with the pair of anti-CD45 monoclonals YTH 24.5 and YTH 54.12. Only two patients elicited a weak human antimurine antibody (HAMA) response.

[Indexed for MEDLINE]

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