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Tuber Lung Dis. 1995 Jun;76(3):248-53.

Humoral immune response in infants after BCG vaccination.

Author information

1
Department of Pediatrics, Medical Faculty, Gazi University, Ankara, Turkey.

Abstract

SETTING:

Child welfare division of a university-based department of pediatrics in Turkey.

OBJECTIVE:

To determine specific IgM and IgG response after BCG vaccination.

DESIGN:

Prospective, randomized trial.

METHODS:

Serum samples of 66 infants were taken before and at 2, 4, 6 and 15 months after vaccination. 35 infants were vaccinated at the first month and 31 at the second month after delivery. An ELISA assay was performed using PPD antigen.

RESULTS:

IgM antibodies increased significantly (P < 0.05) during the post-vaccination period. On the other hand IgG antibodies decreased in the second month after vaccination. At the fourth month the IgG level began to rise continuously (P < 0.01). The infants who were vaccinated at the second month showed a higher IgM response at the second and fourth month than those vaccinated in the first month (P < 0.05), but the difference was not visible thereafter (P > 0.05). 52 infants (78%) were tuberculin positive 8 weeks after vaccination.

CONCLUSION:

Anti-PPD IgM and IgG levels rise progressively in BCG-vaccinated infants.

PMID:
7548909
[Indexed for MEDLINE]

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