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Mech Dev. 1995 Jun;51(2-3):235-49.

Isolation and embryonic expression of Xel-1, a nervous system-specific Xenopus gene related to the elav gene family.

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Laboratoire d'Embryologie Moléculaire et Expérimentale, URA 1134 du Centre National de la Recherche Scientifique, Université Paris XI, Orsay, France.


We have identified a new member of the elav gene family in Xenopus laevis. This gene, Xel-1, like the other elav-related genes, encodes a putative RNA-binding protein that contains three RNA Recognition Motifs and is solely expressed in the nervous system. Xel-1 is most likely the Xenopus homologue of Hel-N1, one of the three known human genes related to elav. Xel-1 is not expressed in early neural precursors but rather in differentiating neurons of the central nervous system, as well as in the cranial and the spinal ganglion cells. Xel-1 thus appears to be an early differentiation marker for both the central and the peripheral nervous system of Xenopus laevis.

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