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Curr Opin Immunol. 1995 Jun;7(3):367-74.

Mouse NK1+ T cells.

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Department of Molecular Biology, Princeton University, New Jersey 08544, USA.


Mouse NK1+ T cells constitute a special subset of alpha beta TCR+ T cells that express natural killer surface receptors and are thought to play an immunoregulatory role because of their unique ability to secrete IL-4 within minutes of primary activation. The recent discovery that they recognize non-polymorphic MHC class I like ligands encoded by CD1 family genes sheds a new light on unusual aspects of their development as well as on some of the possible ways in which they might influence the regulation of the T-helper cell (types 1 and 2) classes of immune responses.

[Indexed for MEDLINE]

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