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Curr Opin Immunol. 1995 Jun;7(3):312-9.

Regulation of immune function by protein tyrosine phosphatases.

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Howard Hughes Medical Institute, Department of Pathology, Washington University School of Medicine, St Louis, MO 63130, USA.


CD45 is a leukocyte transmembrane protein tyrosine phosphatase that functions in lymphocyte activation by increasing the kinase activity of Src family members. In contrast, an intracellular protein tyrosine phosphatase that contains Src homology 2 domains, SHP, is required to inactivate receptors. Recent studies have examined the mechanisms of interaction and regulation of these enzymes.

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