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Immunol Today. 1995 Aug;16(8):383-6.

The role of IL-12 in the induction of organ-specific autoimmune diseases.

Author information

1
Roche Milano Ricerche, Italy.

Abstract

The concept that T cells are subdivided into T helper 1 (Th1) and Th2 subsets was recently extended to suggest that Th1 cells contribute to the pathogenesis of several organ-specific autoimmune diseases, whereas Th2 cells inhibit disease development. Here, Sylvie Trembleau and colleagues examine the role of interleukin 12 (IL-12), a key cytokine guiding the development of Th1 cells, in the induction of autoimmune diseases, and discuss potential immunointervention strategies based on administration of IL-12 antagonists.

PMID:
7546194
DOI:
10.1016/0167-5699(95)80006-9
[Indexed for MEDLINE]

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