Format

Send to

Choose Destination
Immunol Today. 1995 Aug;16(8):374-9.

Th1 and Th2 subsets: paradigms lost?

Author information

1
Transplantation Biology Unit, Queensland Institute of Medical Research, Brisbane, Australia.

Abstract

The T helper 1 (Th1)/Th2 model has provided a valuable framework to investigate and explain many immune reactions and now pervades current thinking on the regulatory role of T cells. However, individual T cells and clones display remarkable diversity in their cytokine profiles, collectively forming a continuous spectrum in which Th1 and Th2 cells may be only two of the possible extreme phenotypes. For these reasons, Anne Kelso argues that cytokine-producing T cells cannot be classified into discrete subsets.

PMID:
7546192
DOI:
10.1016/0167-5699(95)80004-2
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center