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Zh Vyssh Nerv Deiat Im I P Pavlova. 1995 May-Jun;45(3):558-64.

[Inhibitors of NO-synthase and guanylate cyclase block the modulation of cholinoreceptor plasticity in snail neurons by 15-hydroxyeicosatetraenoic acid].

[Article in Russian]


Probable participation of two second messengers, NO and cGMP, in short- and long-latent effects of 15(S)-hydroxy-(5Z,8Z,11Z, 13E)-eicosatetraenoic acid (15-HETE, acyclic eicosanoid) on plasticity of somatic acetylcholine receptors on identified neurons of Helix lucorum was studied using two-electrode voltage clamp technique. It was shown that inhibitor of NO synthase N omega-Methyl-L-Arginine and inhibitors of soluble guanylate cyclase LY-83,583 and methylene blue disturbed short- and long-latent modulatory effects of 15-HETE on depression depth of the inward current evoked by rhythmic acetylcholine application on the neuron soma. We suppose that NO and cGMP participate in short- and long-latent effects of 15-HETE on plasticity of acetylcholine receptors.

[Indexed for MEDLINE]

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