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Trends Biochem Sci. 1995 Jun;20(6):227-31.

Rho as a regulator of the cytoskeleton.

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Department of Molecular Biology and Biochemistry, Osaka University Medical School, Japan.


Many cell functions, including maintenance of morphology, aggregation, motility, membrane ruffling, smooth-muscle contraction, cytokinesis in mammals and bud formation in yeast, are regulated through the dynamic reorganization of actin filaments. Although it has long been known that Ca2+ is a key regulator of the cytoskeleton, evidence is now accumulating that Rho, a Ras-related small GTP-binding protein, is another important regulator of these actin-dependent cell functions.

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