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Oncogene. 1995 Aug 3;11(3):439-45.

IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR.

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GBF--Gesellschaft für Biotechnologische Forschung mbH, Braunschweig, Germany.


Expression of the tumor suppressor IRF-1 results in the inhibition of cell growth and transcriptional activation of the IFN-beta gene. IFN production is not responsible for the IRF-1 mediated cell growth inhibition. It is shown here that activation of the IRF-1 causes induction of PKR expression. PKR is a serine/threonine kinase with tumor suppressor activity. IRF-1 mediated cell growth inhibition and IFN induction correlates with PKR expression. A catalytically inactive dominant negative PKR mutant abolishes both activities of IRF-1. These data demonstrate that the tumor suppressor activity of IRF-1 is mediated, at least in part, by PKR.

[Indexed for MEDLINE]

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