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Science. 1995 Jul 28;269(5223):535-7.

A role for CD5 in TCR-mediated signal transduction and thymocyte selection.

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  • 1Institute for Genetics, University of Cologne, Germany.


CD5 is a transmembrane protein that is expressed on the surface of T cells and a subset of B cells. The absence of CD5 rendered thymocytes hyperresponsive to stimulation through the T cell antigen receptor (TCR) in vitro. Selection of T cells expressing three distinct transgenic TCRs was also abnormal in CD5-deficient mice. These observations indicate that CD5 can influence the fate of developing thymocytes by acting as a negative regulator of TCR-mediated signal transduction.

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