Format

Send to

Choose Destination
Neuron. 1995 Jun;14(6):1201-11.

Differential role of the low affinity neurotrophin receptor (p75) in retrograde axonal transport of the neurotrophins.

Author information

1
Regeneron Pharmaceuticals, Inc., Tarrytown, New York 10591, USA.

Abstract

The receptor mechanisms mediating the retrograde axonal transport of the neurotrophins have been investigated in adult rats. We show that transport of the TrkB ligands NT-4 and BDNF to peripheral neurons is dependent on the low affinity neurotrophin receptor (LNR). Pharmacological manipulation of LNR in vivo using either an anti-LNR antibody or a soluble recombinant LNR extracellular domain completely blocked retrograde transport of NT-4 and BDNF to sensory neurons, while having minimal effects on the transport of NGF in either sensory or sympathetic neurons. Furthermore, in mice with a null mutation of LNR, the transport of NT-4 and BDNF, but not NGF, was dramatically reduced. These observations demonstrate a selective role for LNR in retrograde transport of the various neurotrophins from distinct target regions in vivo.

PMID:
7541633
DOI:
10.1016/0896-6273(95)90267-8
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center