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Exp Cell Res. 1995 Jun;218(2):479-84.

Mechanical induction of beta 1-integrin-mediated calcium signaling in a hepatocyte cell line.

Author information

1
Department of Internal Medicine, University of Rostock, Germany.

Abstract

Mechanical stress influences growth, differentiation, and gene expression in a variety of cell types. It is believed that via extracellular matrix the mechanical stimulus is transmitted to integrin receptors which thus play a key role in transducing signals into the cell interior. Here we demonstrate that incubation of suspended hepatocytes with specific antibodies to beta 1-integrin subunits followed by a short-term mechanical stimulation is sufficient to induce a rise in intracellular Ca2+. The results indicate that mechanical loading of individual integrin subunits activates Ca(2+)-specific signal pathways.

PMID:
7540984
DOI:
10.1006/excr.1995.1181
[Indexed for MEDLINE]

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