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Clin Infect Dis. 1995 Apr;20(4):883-9.

Presumed central nervous system Whipple's disease in a child: case report.

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Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.


Whipple's disease is a rare, chronic, multisystem illness that is pathologically characterized by the accumulation of macrophages in the involved tissue that have a positive periodic acid-Schiff reaction. It is typically seen in middle-aged white men, and only four cases involving persons younger than 15 years of age have been reported. CNS Whipple's disease without intestinal manifestations is rare; only six cases have been reported in the literature, all involving adults. We report the case of a young boy with clinical, laboratory, radiographic, and pathological signs and symptoms consistent with CNS Whipple's disease who responded to therapy with trimethoprimsulfamethoxazole.

[Indexed for MEDLINE]

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